10. OHS: definition, diagnosis, pathophysiology and management 131 Juan Fernando Masa, Jean Paul Janssens, Jean Christian Borel and Jean-Louis Pépin 11. Specific diagnosis and clinical pathways in at-risk populations 147 Eusebi Chiner, José N. Sancho-Chust and Ferran Barbé 12. COPD and other pulmonary diseases 161 José M. Marin 13. Traffic accident risk 179 Vinod Palissery, Akshay Dwarakanath and Mark Elliott Clinical scenarios/pathways 14. Resistant hypertension 191 Miguel Ángel Martinez-García, Francisco Campos-Rodríguez, María José Selma Ferrer and Cristina Navarro Soriano 15. Cancer: an epidemiological perspective 205 F. Javier Nieto 16. Metabolic syndrome 221 Maria R. Bonsignore and Paschalis Steiropoulos Treatment and management 17. Lifestyle intervention and pharmaceutical therapies of sleep apnoea 238 Ding Zou and Jan Hedner 18. Mandibular advancement devices 253 Fernanda R. de Almeida, Peter Cistulli, Bernard Fleury and Frederic Gagnadoux 19. New ventilator support in complex phenotypes: coexisting CSA and OSA 266 Winfried J. Randerath 20. Supporting patients receiving CPAP treatment: the role of training 280 and telemedicine Valentina Isetta, Mireia Ruiz, Ramon Farré and Josep M. Montserrat 21. Integrated care 293 Ching Li Chai-Coetzer, Nick Antic and R. Doug McEvoy 22. Overall treatment strategies 305 Patrick Lévy, Jean-Louis Pépin, Renaud Tamisier and Sandrine Launois-Rollinat