Contents Preface v Guest Editors vii Introduction x List of abbreviations xii 1. Epidemiology 1 Vidya Navaratnam, Doug L. Forrester and Richard B. Hubbard 2. Genetics 16 Raphael Borie, Caroline Kannengiesser, Nadia Nathan and Bruno Crestani 3. Pathogenesis 35 Benjamin Loeh, Martina Korfei, Poornima Mahavadi, Roxana Wasnick, Daniel von der Beck and Andreas Günther 4. Key diagnostic issues 50 Dominique Valeyre, Florence Jeny, Olivia Freynet and Hilario Nunes 5. Histopathology and cryobiopsy 57 Venerino Poletti, Sara Tomassetti, Claudia Ravaglia, Alessandra Dubini, Sara Piciucchi, Alberto Cavazza and Marco Chilosi 6. Bronchoalveolar lavage 74 Tiago M. Alfaro and Carlos Robalo Cordeiro 7. Imaging 82 Simon L.F. Walsh 8. The evaluation of disease severity/staging for prognosis 97 Oisin J. O’Connell and Jim J. Egan 9. Monitoring 106 Katrin Milger and Jürgen Behr 10. Biomarkers 122 Maria A. Kokosi, Elisabetta Renzoni and Francesco Bonella ERS monograph Idiopathic Pulmonary Fibrosis Number 71 March 2016