Preface v Guest Editors vi Introduction viii List of abbreviations x Pathogenesis 1. Animal and physiological settings of IH exposure 1 Renaud Tamisier, Anne Briançon, Patrick Lévy and Jean-Louis Pépin 2. Physiological phenotypes 9 Danny Joel Eckert and Andrew Wellman 3. Cancer: insights into biological plausibility 24 Isaac Almendros, David Gozal and Ramon Farré 4. Cardiovascular disease: pathophysiological mechanisms 37 Manuel Sánchez-de-la-Torre, Maria R. Bonsignore and Ferran Barbé 5. Pathophysiological interactions of OSA, HF and nocturnal fluid 51 redistribution Owen D. Lyons and T. Douglas Bradley OSA in at-risk populations 6. Women and pregnancy 66 Francisco Campos-Rodríguez, Maria J. Masdeu-Margalef and Miguel Ángel Martinez-García 7. Elderly patients 90 Frédéric Roche, David Hupin, Magali Saint-Martin and Emilia Sforza 8. Bariatric surgery 103 Sheila Sivam, Camilla M. Hoyos, Brendon J. Yee, Craig L. Phillips and Ronald R. Grunstein 9. Children 115 Hui-Leng Tan, David Gozal and Leila Kheirandish-Gozal ERS monograph Contents Obstructive Sleep Apnoea Number 67 March 2015